Signer-Hasler, Heidi; Neuditschko, Markus; Koch, Christoph; Froidevaux, Sylvie; Flury, Christine; Burger, Dominik; Leeb, Tosso; Rieder, Stefan; Palau, Francesc (2014). A Chromosomal Region on ECA13 Is Associated with Maxillary Prognathism in Horses PLoS One, 9(1), e86607. Public Library of Science (PLoS) 10.1371/journal.pone.0086607
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Hereditary variations in head morphology and head malformations are known in many species. The most common variation encountered in horses is maxillary prognathism. Prognathism and brachygnathism are syndromes of the upper and lower jaw, respectively. The resulting malocclusion can negatively affect teeth wear, and is considered a non-desirable trait in breeding programs. We performed a case-control analysis for maxillary prognathism in horses using 96 cases and 763 controls. All horses had been previously genotyped with a commercially available 50 k SNP array. We analyzed the data with a mixed-model considering the genomic relationships in order to account for population stratification. Two SNPs within a region on the distal end of chromosome ECA 13 reached the Bonferroni corrected genome-wide significance level. There is no known prognathism candidate gene located within this region. Therefore, our findings in the horse offer the possibility of identifying a novel gene involved in the complex genetics of prognathism that might also be relevant for humans and other livestock species.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
School of Agricultural, Forest and Food Sciences HAFL > Resource-efficient agricultural production systems School of Agricultural, Forest and Food Sciences HAFL > Agriculture |
Name: |
Signer-Hasler, Heidi 0000-0001-5193-5306; Neuditschko, Markus; Koch, Christoph; Froidevaux, Sylvie; Flury, Christine; Burger, Dominik; Leeb, Tosso; Rieder, Stefan and Palau, Francesc |
Subjects: |
S Agriculture > SF Animal culture |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science (PLoS) |
Language: |
English |
Submitter: |
David Zimmer |
Date Deposited: |
04 Oct 2019 12:17 |
Last Modified: |
03 Nov 2023 09:56 |
Publisher DOI: |
10.1371/journal.pone.0086607 |
ARBOR DOI: |
10.24451/arbor.8245 |
URI: |
https://arbor.bfh.ch/id/eprint/8245 |
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