Unsupervised Exercise Training Was Not Found to Improve the Metabolic Health or Phenotype over a 6-Month Dietary Intervention: A Randomised Controlled Trial with an Embedded Economic Analysis

Hens, Wendy; Vissers, Dirk; Verhaeghe, Nick; Gielen, Jan; Van Gaal, Luc; Taeymans, Jan (2021). Unsupervised Exercise Training Was Not Found to Improve the Metabolic Health or Phenotype over a 6-Month Dietary Intervention: A Randomised Controlled Trial with an Embedded Economic Analysis International Journal of Environmental Research and Public Health, 18(15), pp. 1-13. MDPI 10.3390/ijerph18158004

Preview

Text Unsupervised Exercise Training Was Not Found to Improve the Metabolic Health or Phenotyp.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview

Abstract Ectopic fat leads to metabolic health problems. This research aimed to assess the effectiveness of a hypocaloric diet intervention together with an unsupervised exercise training program in comparison with a hypocaloric diet alone to reduce ectopic fat deposition. Sixty-one premenopausal women with overweight or obesity participated in this controlled trial and were each randomised into either a usual care group (hypocaloric diet) or intervention group (hypocaloric diet + unsupervised exercise training). Ectopic fat deposition, metabolic parameters, incremental costs from a societal perspective and incremental quality-adjusted life years (QALYs) were assessed before, during and after the six-month intervention period. In the total sample, there was a significant decrease in visceral adipose tissue (VAT: -18.88 cm2, 95% CI -11.82 to -25.95), subcutaneous abdominal adipose tissue (SAT: -46.74 cm2, 95% CI -29.76 to -63.18), epicardial fat (ECF: -14.50 cm3, 95% CI -10.9 to -18.98) and intrahepatic lipid content (IHL: -3.53%, 95% CI -1.72 to -5.32). Consequently, an "adapted" economic analysis revealed a non-significant decrease in costs and an increase in QALYs after the intervention. No significant differences were found between groups. A multidisciplinary lifestyle approach seems successful in reducing ectopic fat deposition and improving the metabolic risk profile in women with overweight and obesity. The addition of unsupervised exercise training did not further improve the metabolic health or phenotype over the six months. Keywords: body fat distribution; ectopic fat; exercise; overweight.

Item Type:	Journal Article (Original Article)
Division/Institute:	School of Health Professions > Physiotherapy > Public Health & Physiotherapy Related Health Economics
Name:	Hens, Wendy; Vissers, Dirk; Verhaeghe, Nick; Gielen, Jan; Van Gaal, Luc and Taeymans, Jan0000-0003-1583-4043
ISSN:	1660-4601
Publisher:	MDPI
Language:	English
Submitter:	Jan Taeymans
Date Deposited:	24 Jan 2022 15:27
Last Modified:	24 Jan 2022 15:27
Publisher DOI:	10.3390/ijerph18158004
ARBOR DOI:	10.24451/arbor.16378
URI:	https://arbor.bfh.ch/id/eprint/16378