Healthy lifestyle is inversely associated with mortality in cancer survivors: Results from the Third National Health and Nutrition Examination Survey (NHANES III)

Karavasiloglou, Nena; Pestoni, Giulia; Wanner, Miriam; Fäh, David; Rohrmann, Sabine; Cheng, Xianwu (2019). Healthy lifestyle is inversely associated with mortality in cancer survivors: Results from the Third National Health and Nutrition Examination Survey (NHANES III) PLOS ONE, 14(6), pp. 1-11. Public Library of Science 10.1371/journal.pone.0218048

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Individual lifestyle behaviors have been associated with prolonged survival in cancer survivors, but little information is available on the association between combined lifestyle behaviors and mortality in this population. Data from 522 cancer survivors participating in the Third National Health and Nutrition Examination Survey (NHANES III) were analyzed. Behaviors pertaining to lifetime healthy body weight maintenance, physical activity, smoking, diet quality (assessed by the Healthy Eating Index) and moderate alcohol consumption were combined in a lifestyle score (range 0–5). Cox proportional hazards regression models were used to calculate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). Both in continuous and categorical models, the lifestyle score was statistically significantly associated with lower mortality in the total study population (HRcontinuous = 0.81, 95% CI: 072, 0.90, per 1 unit increase; HR1-2 vs. 0 total = 0.71, 95% CI: 0.56, 0.92; HR3-5 vs. 0 total = 0.57, 95% CI: 0.38, 0.85, in the fully adjusted model) and in sex-specific analyses. Cancer survivors with high or moderate lifestyle score had lower risk of premature death compared to survivors with zero lifestyle score. Future studies are required in order to verify our findings and to investigate underlying mechanisms of the mortality-adherence association.

Item Type:

Journal Article (Original Article)

Division/Institute:

Health Professions
Health Professions > Nutrition and Dietetics

Name:

Karavasiloglou, Nena;
Pestoni, Giulia;
Wanner, Miriam;
Fäh, David;
Rohrmann, Sabine and
Cheng, Xianwu

Subjects:

R Medicine > R Medicine (General)

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

David Fäh

Date Deposited:

15 Jan 2020 11:04

Last Modified:

15 Jan 2020 11:04

Publisher DOI:

10.1371/journal.pone.0218048

ARBOR DOI:

10.24451/arbor.10065

URI:

https://arbor.bfh.ch/id/eprint/10065

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