National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : a pooled analysis of 458 population-based studies in Asian and Western countries

Taddei, Cristina; Jackson, Rod; Zhou, Bin; Bixby, Honor; Danaei, Goodarz; Di Cesare, Mariachiara; Kuulasmaa, Kari; Hajifathalian, Kaveh; Bentham, James; Bennett, James E; Aekplakorn, Wichai; Cifkova, Renata; Dallongeville, Jean; DeBacquer, Dirk; Giampaoli, Simona; Gudnason, Vilmundur; Khang, Young-Ho; Laatikainen, Tiina; Mann, JimI; Marques-Vidal, Pedro; ... (2019). National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : a pooled analysis of 458 population-based studies in Asian and Western countries International Journal of Epidemiology, pp. 1-20. Oxford University Press ; HighWire Press 10.1093/ije/dyz099

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Background Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.

Item Type:

Journal Article (Original Article)

Division/Institute:

Department of Health Professions > Abteilung Ernährung und Diätetik
Department of Health Professions
Department of Health Professions > Abteilung Ernährung und Diätetik > Angewandte Forschung und Entwicklung Ernährung und Diätetik

Name:

Taddei, Cristina; Jackson, Rod; Zhou, Bin; Bixby, Honor; Danaei, Goodarz; Di Cesare, Mariachiara; Kuulasmaa, Kari; Hajifathalian, Kaveh; Bentham, James; Bennett, James E; Aekplakorn, Wichai; Cifkova, Renata; Dallongeville, Jean; DeBacquer, Dirk; Giampaoli, Simona; Gudnason, Vilmundur; Khang, Young-Ho; Laatikainen, Tiina; Mann, JimI; Marques-Vidal, Pedro; Mensah, GeorgeA; Müller-Nurasyid, Martina; Ninomiya, Toshiharu; Petkeviciene, Janina; Rodríguez-Artalejo, Fernando; Servais, Jennifer; Söderberg, Stefan; Stavreski, Bill; Wilsgaard, Tom; Zdrojewski, Tomasz; Zhao, Dong; Stevens, Gretchen A; Savin, Stefan; Cowan, Melanie J; Riley, Leanne M; Ezzati, Majid; Adams, Robert J; Aekplakorn, Wichai; Ahrens, Wolfgang; Amouyel, Philippe; Amuzu, Antoinette; Anderssen, Sigmund A; Ariansen, Inger; Arveiler, Dominique; Aspelund, Thor; Auvinen, Juha; Avdicová, Mária; Banach, Maciej; Bandosz, Piotr; Banegas, José R; Barbagallo, Carlo M; Bata, Iqbal; Baur, Louise A; Beaglehole, Robert; Bennett, James E; Bernotiene, Gailute; Bi, Yufang; Bienek, Asako; Björkelund, Cecilia; Bo, Simona; Boehm, Bernhard O; Bonaccio, Marialaura; Bongard, Vanina; Borchini, Rossana; Borghs, Herman; Breckenkamp, Juergen; Brenner, Hermann; Bruno, Graziella; Busch, Markus A; CabreradeLeón, Antonio; Capuano, Vincenzo; Casanueva, Felipe F; Casas, Juan-Pablo; Caserta, Carmelo A; Censi, Laura; Chen, Fangfang; Chen, Shuohua; Chirlaque, María-Dolores; Cho, Belong; Cho, Yumi; Chudek, Jerzy; Cifkova, Renata; Claessens, Frank; Clarke, Janine; Clays, Els; Cooper, Cyrus; Costanzo, Simona; Cottel, Dominique; Cowell, Chris; Crujeiras, AnaB; Cui, Liufu; D'Arrigo, Graziella; Dallongeville, Jean; Dauchet, Luc; De Backer, Guy; De Bacquer, Dirk; de Gaetano, Giovanni; De Henauw, Stefaan; De Smedt, Delphine; Dennison, Elaine; Deschamps, Valérie; DiCastelnuovo, Augusto; Dobson, Annette J; Donfrancesco, Chiara; Döring, Angela; Drygas, Wojciech; Du, Yong; Dziankowska-Zaborszczyk, Elzbieta; Eggertsen, Robert; Ekelund, Ulf; Elosua, Roberto; Eriksson, JohanG; Evans, Alun; Fäh, David; Felix-Redondo, Francisco J; Fernández-Bergés, Daniel; Ferrari, Marika; Ferrieres, Jean; Finn, JosephD; Forslund, Ann-Sofie; Forsner, Maria; Frontera, Guillermo; Fujita, Yuki; Gaciong, Zbigniew; Galvano, Fabio; Gao, Jingli; Garcia-de-la-Hera, Manoli; Garnett, SarahP; Gaspoz, Jean-Michel; Gasull, Magda; Gates, Louise; Giampaoli, Simona; Gianfagna, Francesco; Gill, Tiffany K; Giovannelli, Jonathan; Goltzman, David; GonzalezGross, Marcela; Gottrand, Frederic; Graff-Iversen, Sidsel; Grafnetter, Dušan; Gregor, Ronald D; Grodzicki, Tomasz; Grosso, Giuseppe; Gruden, Grabriella; Gu, Dongfeng; Guallar-Castillón, Pilar; Gudmundsson, EliasF; Gudnason, Vilmundur; Guessous, Idris; Gunnlaugsdottir, Johanna; Gutzwiller, Felix; Hardy, Rebecca; Hata, Jun; Haugsgjerd, Teresa; Hayes, Alison J; He, Jiang; He, Yuna; Herrala, Sauli; TapaniHihtaniemi, Ilpo; Hobbs, Michael; Hopman, Wilma M; MaríaHuerta, José; Huybrechts, Inge; Iacoviello, Licia; Iannone, Anna G; Ikeda, Nayu; Iwasaki, Masanori; Jackson, Rod; Jamrozik, Konrad; Janszky, Imre; Jarvelin, Marjo-Riitta; Jasienska, Grazyna; Jennings, Garry; Jeong, Seung-lyeal; QiangJiang, Chao; Joffres, Michel; Jokelainen, Jari J; Jonas, Jost B; Jóźwiak, Jacek; Kajantie, Eero O; Kauhanen, Jussi; Keil, Ulrich; Keinänen-Kiukaanniemi, Sirkka; Kersting, Mathilde; Khang, Young-Ho; Kiechl-Kohlendorfer, Ursula; Kiechl, Stefan; Kim, Jeongseon; Kim, Yeon-Yong; Klumbiene, Jurate; Knoflach, Michael; Ko, Stephanie; Kolle, Elin; Korpelainen, Raija; Koskinen, Seppo; Kouda, Katsuyasu; Kratzer, Wolfgang; Kriemler, Susi; Krokstad, Steinar; Kujala, UrhoM; Kurjata, Pawel; Kuulasmaa, Kari; Laatikainen, Tiina; HingLam, Tai; Lanska, Vera; Lappas, Georg; Laugsand, LarsE; Lee, Jeonghee; Lehtimäki, Terho; Li, Yanping; Lilly, Christa L; Lin, Xu; Lind, Lars; Lissner, Lauren; Liu, Jing; Lopez-Garcia, Esther; Lorbeer, Roberto; EugenioLozano, José; Luksiene, Dalia; Lundqvist, Annamari; Lundqvist, Robert; Lytsy, Per; Ma, Guansheng; Machi, Suka; Maggi, Stefania; Magliano, Dianna J; Mann, JimI; Manzato, Enzo; Marques-Vidal, Pedro; Mathiesen, Ellisiv B; McLachlan, Stela; McLean, Rachael M; Scott, B; Meirhaeghe, Aline; Metcalf, Patricia; Mi, Jie; Miller, Jody C; Moreno, Luis A; Morin, Suzanne; Mossakowska, Malgorzata; Muiesan, Maria L; Müller-Nurasyid, Martina; Mursu, Jaakko; Nakamura, Harunobu; Námešná, Jana; MariaNavarrete-Muñoz, Eva; Neal, William A; Nenko, Ilona; Niiranen, Teemu J; Ning, Guang; Ninomiya, Toshiharu; Noale, Marianna; Norie, Sawada; Noto, Davide; O'Neill, Terence; O'Reilly, Dermot; Oh, Kyungwon; Olafsson, Örn; MichelPaccaud, Fred; Pajak, Andrzej; Palmieri, Luigi; Panza, Francesco; Parnell, Winsome R; Peltonen, Markku; Peters, Annette; Petersmann, Astrid; Petkeviciene, Janina; Pigeot, Iris; Pilotto, Lorenza; Piwonska, Aleksandra; Plans-Rubió, Pedro; Porta, Miquel; Price, Jacqueline F; Puder, Jardena J; Puhakka, Soile E; Radisauskas, Ricardas; Raitakari, Olli; Ramos, Rafel; Redon, Josep; Rigo, Fernando; Rodríguez-Artalejo, Fernando; Rodriguez-Perez, María del Cristo; Romaguera, Dora; Ronkainen, Kimmo; Rosengren, Annika; Roy, Joel G R; Ruidavets, Jean-Bernard; Rutkowski, Marcin; Salanave, Benoit; Salmerón, Diego; Salomaa, Veikko; Salonen, Jukka T; Salvetti, Massimo; Sans, Susana; Saramies, Jouko L; Saum, Kai-Uwe; Scheidt-Nave, Christa; Schienkiewitz, Anja; Schipf, Sabine; Schmidt, Carsten O; Schöttker, Ben; Sebert, Sylvain; Sen, Abhijit; Servais, Jennifer; Shaw, Jonathan E; Shibuya, Kenji; WookShin, Dong; Shiri, Rahman; Simons, Judith; Simons, Leon A; Sjöström, Michael; Slowikowska-Hilczer, Jolanta; Slusarczyk, Przemyslaw; Söderberg, Stefan; Solfrizzi, Vincenzo; Sonestedt, Emily; Soumare, Aicha; Staessen, Jan A; Stathopoulou, Maria G; Stavreski, Bill; Steene-Johannessen, Jostein; Stehle, Peter; Stieber, Jutta; Stöckl, Doris; Stokwiszewski, Jakub; Sundström, Johan; Suriyawongpaisal, Paibul; Tamosiunas, Abdonas; JooTan, Eng; Taylor, Anne; Tell, Grethe; Thijs, Lutgarde; Tolonen, Hanna K; Topór-Madry, Roman; JoséTormo, María; Torrent, Maties; Tsugane, Shoichiro; Tuomainen, Tomi-Pekka; Tuomilehto, Jaakko; Tzourio, Christophe; Uusitalo, Hannu M T; VanHerck, Koen; Vanderschueren, Dirk; Vanuzzo, Diego; Vatten, Lars; Vega, Tomas; Veronesi, Giovanni; Vioque, Jesus; Virtanen, JyrkiK; Visvikis-Siest, Sophie; Vollenweider, Peter; Voutilainen, Sari; Vrijheid, Martine; Wagner, Aline; Wagner, Anne; Wang, Ming-Dong; Wang, Qian; XingWang, Ya; Goya Wannamethee, S; Wei, Wenbin; Whincup, Peter H; Wiecek, Andrzej; Willeit, Johann; Willeit, Peter; Wilsgaard, Tom; Wojtyniak, Bogdan; Wong, Andrew; Woodward, Mark; GiwercmanWu, Aleksander; Wu, Frederick C; Wu, Shouling; Xu, Haiquan; Xu, Liang; Yan, Weili; Yang, Xiaoguang; Ye, Xingwang; Yoshihara, Akihiro; Zambon, Sabina; Zdrojewski, Tomasz; Zhao, Dong and Zhao, Wenhua

Subjects:

R Medicine > R Medicine (General)

ISSN:

0300-5771

Publisher:

Oxford University Press ; HighWire Press

Language:

English

Submitter:

David Fäh

Date Deposited:

13 Jan 2020 16:35

Last Modified:

28 Apr 2020 11:57

Publisher DOI:

10.1093/ije/dyz099

ARBOR DOI:

10.24451/arbor.10063

URI:

https://arbor.bfh.ch/id/eprint/10063

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