Merker, MeretMeretMerkerAmsler, AlineAlineAmslerPereira, RenataRenataPereiraBolliger, RebekkaRebekkaBolligerTribolet, PascalPascalTriboletBraun, NinaNinaBraunHoess, ClausClausHoessPavlicek, VojtechVojtechPavlicekBilz, StefanStefanBilzSigrist, SarahSarahSigristBrändle, MichaelMichaelBrändleHenzen, ChristophChristophHenzenThomann, RobertRobertThomannRutishauser, JonasJonasRutishauserAujesky, DrahomirDrahomirAujeskyRodondi, NicolasNicolasRodondiDonzé, JaquesJaquesDonzéStanga, ZenoZenoStangaMueller, BeatBeatMuellerSchuetz, PhilippPhilippSchuetz2024-11-192024-11-192019-110025-797410.24451/arbor.11784https://doi.org/10.24451/arbor.1178410.1097/MD.0000000000018113https://arbor.bfh.ch/handle/arbor/40905The impact of vitamin D deficiency on the recovery of patients with malnutrition remains undefined. Our aim was to study the prevalence of vitamin D deficiency in a well-characterized cohort of patients with malnutrition and its association with outcomes.Within this secondary analysis of a randomized controlled trial, we examined the association of vitamin D deficiency and adverse clinical outcomes over a follow-up of 180 days in hospitalized patients at risk for malnutrition. We measured 25-hydroxyvitamin D levels upon admission and defined Vitamin D deficiency when levels were <50nmol/l. The primary endpoint was 180-day mortality.The prevalence of vitamin D deficiency in our cohort of 828 patients was 58.2% (n = 482). Patients with vitamin D deficiency had increased 180-day mortality rates from 23.1% to 29.9% (odds ratio 1.42, 95% confidence interval [CI] 1.03-1.94, P = .03). When adjusting the analysis for demographics, comorbidities, and randomization, this association remained significant for the subgroup of patients not receiving vitamin D treatment (adjusted odds ratio 1.63, 95% CI 1.01-2.62, P = .04). There was no significantly lower risk for mortality in the subgroup of vitamin D deficient patients receiving vitamin D treatment compared to not receiving treatment (adjusted odds ratio 0.74, 95% CI 0.48-1.13, P = .15).Vitamin D deficiency is highly prevalent in the population of malnourished inpatients and is negatively associated with long-term mortality particularly when patients are not receiving vitamin D treatment. Our findings suggest that malnourished patients might benefit from vitamin D screening and treatment in case of deficiency.enarticle