Burri, Christian; Salzmann, Simon Adrian; Wandel, Jasmin; Hoffmann, Leonie; Povazay, Boris; Meier, Christoph; Frenz, Martin (2023). Real-time OCT feedback-controlled RPE photodisruption in ex vivo porcine eyes using 8 microsecond laser pulses Biomedical Optics Express, 14(12), p. 6328. Optica 10.1364/BOE.503941
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Selective retinal pigment epithelium (RPE) photodisruption requires reliable real-time feedback dosimetry (RFD) to prevent unwanted overexposure. In this study, optical coherence tomography (OCT) based RFD was investigated in ex vivo porcine eyes exposed to laser pulses of 8 µs duration (wavelength: 532 nm, exposure area: 90 × 90 µm2, radiant exposure: 247 to 1975 mJ/µm2). For RFD, fringe washouts in time-resolved OCT M-scans (central wavelength: 870 nm, scan rate: 85 kHz) were compared to an RPE cell viability assay. Statistical analysis revealed a moderate correlation between RPE lesion size and applied treatment energy, suggesting RFD adaptation to inter- and intraindividual RPE pigmentation and ocular transmission.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
School of Engineering and Computer Science > Institute for Human Centered Engineering (HUCE) School of Engineering and Computer Science > Institute for Human Centered Engineering (HUCE) > HUCE / Laboratory for Optics School of Engineering and Computer Science |
Name: |
Burri, Christian 0000-0003-2690-7527; Salzmann, Simon Adrian 0000-0001-5453-8808; Wandel, Jasmin; Hoffmann, Leonie; Povazay, Boris 0000-0001-5571-5116; Meier, Christoph and Frenz, Martin |
Subjects: |
Q Science > Q Science (General) Q Science > QC Physics R Medicine > R Medicine (General) R Medicine > RE Ophthalmology T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) |
ISSN: |
2156-7085 |
Publisher: |
Optica |
Language: |
English |
Submitter: |
Christian Burri |
Date Deposited: |
08 Dec 2023 12:09 |
Last Modified: |
12 Dec 2023 14:33 |
Publisher DOI: |
10.1364/BOE.503941 |
ARBOR DOI: |
10.24451/arbor.20613 |
URI: |
https://arbor.bfh.ch/id/eprint/20613 |
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