Exercise-based rehabilitation reduces reinjury following acute lateral ankle sprain: A systematic review update with meta-analysis

Wagemans, Jente; Bleakley, Chris; Taeymans, Jan; Schurz, Alexander Philipp; Kuppens, Kevin; Baur, Heiner; Vissers, Dirk (2022). Exercise-based rehabilitation reduces reinjury following acute lateral ankle sprain: A systematic review update with meta-analysis PLoS One, 17(2), :e0262023. Public Library of Science (PLoS) 10.1371/journal.pone.0262023

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Research questions: 1) Do exercise-based rehabilitation programs reduce re-injury following acute ankle sprain?; 2) Is rehabilitation effectiveness moderated by the exercise's therapeutic quality, content and volume? Methods: This systematic review with meta-analysis (PROSPERO: CRD42020210858) included randomized controlled trials in which adults who sustained an acute ankle sprain received exercise-based rehabilitation as an intervention. Databases CINAHL, Web of Science, SPORTDiscus, Cochrane Central Register of Controlled Trials, PEDro and Google Scholar were searched for eligible articles (last search: March 2021). ROB II screening tool by Cochrane was used to assess risk of bias and the i-CONTENT tool was used to assess quality of interventions. Both qualitative analysis and quantitative data synthesis were performed. Results: Fourteen randomized controlled trials comprising 2182 participants were included. Five studies were judged overall low risk of bias and i-CONTENT assessment showed poor to moderate therapeutic quality of exercise across all included articles. Pooled data found significant reductions in re-injury prevalence at 12 months, in favour of the exercise-based rehabilitation group vs usual care (OR: 0.60; 95%CI: 0.36 to 0.99). Pooled data for re-injury incidence showed not-significant results (MD: 0.027; 95%CI: -2.14 to 2.19). Meta-regression displayed no statistically significant association between training volume and odds of re-injury (r = -0.00086; SD: 0.00057; 95%CI: -0.00197 to 0.00025). Results from patient-reported outcomes and clinical outcomes were inconclusive at 1 month, 3-6 months and 7-12 months of follow up. Conclusion: Exercise-based rehabilitation reduces the risk of recurrent ankle sprain compared to usual care, but there is insufficient data to determine the optimal content of exercise-based interventions. Training volume varied considerably across studies but did not affect the odds of sustaining a re-injury. Effects on patient-reported outcomes and clinical outcomes are equivocal. Future research should compare different exercise contents, training volumes and intensities after ankle sprain.

Item Type:

Journal Article (Original Article)

Division/Institute:

School of Health Professions
School of Health Professions > Physiotherapy
School of Health Professions > Physiotherapy > Foot Biomechanics and Technology
School of Health Professions > Physiotherapy > Neuromuscular Control

Name:

Wagemans, Jente;
Bleakley, Chris;
Taeymans, Jan;
Schurz, Alexander Philipp0000-0002-2818-0782;
Kuppens, Kevin;
Baur, Heiner0000-0002-4780-225X and
Vissers, Dirk

Subjects:

Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
R Medicine > RZ Other systems of medicine

ISSN:

1932-6203

Publisher:

Public Library of Science (PLoS)

Language:

English

Submitter:

Heiner Baur

Date Deposited:

12 Sep 2022 15:18

Last Modified:

03 Nov 2023 09:50

Publisher DOI:

10.1371/journal.pone.0262023

PubMed ID:

35134061

ARBOR DOI:

10.24451/arbor.17695

URI:

https://arbor.bfh.ch/id/eprint/17695

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