The impact of nutritional support on malnourished inpatients with aging-related vulnerability

Baumgartner, Annic; Pachnis, Daphne; Parra, Lucie; Hersberger, Lara; Bargetzi, Annika; Bargetzi, Laura; Kaegi-Braun, Nina; Tribolet, Pascal; Gomes, Filomena; Hoess, Claus; Pavlicek, Vojtech; Bilz, Stefan; Sigrist, Sarah; Braendle, Michael; Henzen, Christoph; Thomann, Robert; Rutishauser, Jonas; Aujesky, Drahomir; Rodondi, Nicolas; Donzé, Jacques; ... (2021). The impact of nutritional support on malnourished inpatients with aging-related vulnerability Nutrition, 89, p. 111279. Elsevier 10.1016/j.nut.2021.111279

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Objectives: Malnutrition is highly prevalent in patients with aging-related vulnerability defined by very old age (�80 y), physical frailty or cognitive impairment, and increases the risks for morbidity and mortality. The effects of individualized nutritional support for patients with aging-related vulnerability in the acute hospital setting on mortality and other clinical outcomes remains understudied. Methods: For this secondary analysis of the randomized-controlled Effect of Early Nutritional Support on Frailty, Functional Outcomes, and Recovery of Malnourished Medical Inpatients Trial (EFFORT), we analyzed data of patients at a nutritional risk (Nutritional Risk Screening 2002 score �3 points) with aging-related vulnerability, randomized to receive protocol-guided individualized nutritional support to reach specific protein and energy goals (intervention group) or routine hospital food (control group). The primary endpoint was all-cause 30-d mortality. Results: Of the 881 patients with aging-related vulnerability, 23.4% presented with a frailty syndrome, 81.8% were age �80 y and 15.3% showed cognitive impairment. Patients with aging-related vulnerability receiving individualized nutritional support compared with routine hospital food showed a >50% reduction in the risk of 30-day mortality (60 of 442 [13.6%] versus 31 of 439 [7.1%]; odds ratio: 0.48; 95% confidence interval, 0.31�0.76; P = 0.002). Significant improvements were also found for long-term mortality at 180 days, as well as functional outcomes and quality of life measures.

Item Type:	Journal Article (Original Article)
Division/Institute:	School of Health Professions > Nutrition and Dietetics
Name:	Baumgartner, Annic; Pachnis, Daphne; Parra, Lucie; Hersberger, Lara; Bargetzi, Annika; Bargetzi, Laura; Kaegi-Braun, Nina; Tribolet, Pascal; Gomes, Filomena; Hoess, Claus; Pavlicek, Vojtech; Bilz, Stefan; Sigrist, Sarah; Braendle, Michael; Henzen, Christoph; Thomann, Robert; Rutishauser, Jonas; Aujesky, Drahomir; Rodondi, Nicolas; Donzé, Jacques; Stanga, Zeno; Mueller, Beat and Schuetz, Philipp
Subjects:	R Medicine > R Medicine (General)
ISSN:	0899-9007
Publisher:	Elsevier
Language:	English
Submitter:	Pascal Tribolet
Date Deposited:	17 Jan 2022 15:03
Last Modified:	17 Jan 2022 15:03
Publisher DOI:	10.1016/j.nut.2021.111279
ARBOR DOI:	10.24451/arbor.16228
URI:	https://arbor.bfh.ch/id/eprint/16228