What is bio-banding? During adolescents the biological age (BA) can vary up to five years among athletes with the same chronological age (CA). Bio-banding matches the training and competition groups according to BA rather than the CA. Aim of the review article The aim of the review was to summaries the advantages and limitations of Bio-banding and give practical recommendations for its use in junior soccer players. Advantages and limitations Bio-banding results in more homogenous training and competition groups and provides opportunities for both, early and late maturing players. During duels, the early maturing players develop their technical-tactical skills rather than taking advantage of their stronger physics. Also, early developed players cannot dominate the game as much as in training and competition groups based on the CA. They learn to handle winning and losing in a proper relationship. The overall accelerated game play challenges their quick decision-making skills. Late developed players on the other hand are able to duel with equally strong and heavy opponents. They learn to take on responsibility and leadership in the team. By receiving more playing time, more attention and positive feedback by the coaches, selection chances for late maturing players are improved and the drop-out rate might be reduced. Even the injury rate might be reduced with the decreasing differences in body weight and strength between the early and late developing players. Bio-banding, however, has limitations. While the best method to determine the BA is still discussed, the player’s psycho-social development does not always match their physical maturity. In the process of becoming a top performer, late maturing and highly skilled players might benefit from the challenging environment provided by the early developed players according to the so-called ‘under-dog theory’. A combination of games with the teams matched by BA as well as CA over the time course of the season might be of advantage. Conclusion Bio-banding might improve the talent development in junior soccer players. Future research needs to find the age on when to best begin with the bio-bands. The effects of bio-banding on the long-term development and selection process of junior soccer players is still unclear and the best ratio of traditional and bio-banded game play needs to be investigated.