Engineering of ecological niches to create stable artificial consortia for complex biotransformations

Shahab, Robert L.; Brethauer Studer, Simone; Luterbacher, Jeremy S.; Studer, Michael Hans-Peter (2020). Engineering of ecological niches to create stable artificial consortia for complex biotransformations Current Opinion in Biotechnology, 62, pp. 129-136. Elsevier 10.1016/j.copbio.2019.09.008

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The design of controllable artificial microbial consortia has attracted considerable interest in recent years to capitalize on the inherent advantages in comparison to monocultures such as the distribution of the metabolic burden by division of labor, the modularity and the ability to convert complex substrates. One promising approach to control the consortia composition, function and stability is the provision of defined ecological niches fitted to the specific needs of the consortium members. In this review, we discuss recent examples for the creation of metabolic niches by biological engineering of resource partitioning and syntrophic interactions. Moreover, we introduce a complementing process engineering approach to provide defined spatial niches with differing abiotic conditions (e.g. O2, T, light) in stirred tank reactors harboring biofilms. This enables the co-cultivation of microorganisms with non-overlapping abiotic requirements and the control of the strain ratio in consortia characterized by substrate competition.

Item Type:

Journal Article (Original Article)

Division/Institute:

School of Agricultural, Forest and Food Sciences HAFL > Resource-efficient agricultural production systems
School of Agricultural, Forest and Food Sciences HAFL > Agriculture

Name:

Shahab, Robert L.;
Brethauer Studer, Simone0000-0001-7755-7593;
Luterbacher, Jeremy S. and
Studer, Michael Hans-Peter0000-0003-1083-0967

Subjects:

Q Science > QD Chemistry
T Technology > T Technology (General)

ISSN:

09581669

Publisher:

Elsevier

Funders:

Organisations 407040 not found.
[UNSPECIFIED] Swiss Confederation through Innosuisse–SwissInnovationAgency

Language:

English

Submitter:

Michael Hans-Peter Studer

Date Deposited:

27 Jan 2020 08:12

Last Modified:

18 Dec 2020 13:29

Publisher DOI:

10.1016/j.copbio.2019.09.008

ARBOR DOI:

10.24451/arbor.9835

URI:

https://arbor.bfh.ch/id/eprint/9835

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