Shahab, Robert L.; Brethauer Studer, Simone; Luterbacher, Jeremy S.; Studer, Michael Hans-Peter (2020). Engineering of ecological niches to create stable artificial consortia for complex biotransformations Current Opinion in Biotechnology, 62, pp. 129-136. Elsevier 10.1016/j.copbio.2019.09.008
|
Text
Shahab 2020 Engineering of ecological niches to create stable artificial consortia.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview |
The design of controllable artificial microbial consortia has attracted considerable interest in recent years to capitalize on the inherent advantages in comparison to monocultures such as the distribution of the metabolic burden by division of labor, the modularity and the ability to convert complex substrates. One promising approach to control the consortia composition, function and stability is the provision of defined ecological niches fitted to the specific needs of the consortium members. In this review, we discuss recent examples for the creation of metabolic niches by biological engineering of resource partitioning and syntrophic interactions. Moreover, we introduce a complementing process engineering approach to provide defined spatial niches with differing abiotic conditions (e.g. O2, T, light) in stirred tank reactors harboring biofilms. This enables the co-cultivation of microorganisms with non-overlapping abiotic requirements and the control of the strain ratio in consortia characterized by substrate competition.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
School of Agricultural, Forest and Food Sciences HAFL > Resource-efficient agricultural production systems School of Agricultural, Forest and Food Sciences HAFL > Agriculture |
Name: |
Shahab, Robert L.; Brethauer Studer, Simone  0000-0001-7755-7593; Luterbacher, Jeremy S. and Studer, Michael Hans-Peter 0000-0003-1083-0967 |
Subjects: |
Q Science > QD Chemistry T Technology > T Technology (General) |
ISSN: |
09581669 |
Publisher: |
Elsevier |
Funders: |
Organisations 407040 not found.; [UNSPECIFIED] Swiss Confederation through Innosuisse–SwissInnovationAgency |
Language: |
English |
Submitter: |
Michael Hans-Peter Studer |
Date Deposited: |
27 Jan 2020 08:12 |
Last Modified: |
18 Dec 2020 13:29 |
Publisher DOI: |
10.1016/j.copbio.2019.09.008 |
ARBOR DOI: |
10.24451/arbor.9835 |
URI: |
https://arbor.bfh.ch/id/eprint/9835 |
Actions (login required)
 |
View Item |