Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

Burri, Christian; Hutfilz, Alessa; Grimm, Lorenz Sebastian; Arnold, Patrik; Ebneter, Andreas; Brinkmann, Ralf; Theisen-Kunde, Dirk; Povazay, Boris; Meier, Christoph; Lilge, Lothar D.; Philipp, Carsten M. (2019). Optical coherence tomography controlled selective retina therapy with a novel microsecond laser Proceedings SPIE : Medical Laser Applications and Laser-Tissue Interactions IX, 11079, p. 2. SPIE 10.1117/12.2526720

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Selective retina therapy (SRT) is a short pulse (μs-regime) alternative to conventional laser photocoagulation (LPC) for treatment of retinal diseases. LPC leads to collateral damage of retinal layers adjacent to the retinal pigment epithelium (RPE), including healthy, non-regenerative photoreceptors due to the high thermal load, whereas in SRT, RPE cells are destroyed by microbubbles without damaging the neuronal retina. A novel experimental SRT laser operating at 532 nm wavelength can deliver 2 – 20 μs pulse sequences. Its tight integration into an upgraded diagnostic SPECTRALIS system combines beam control for treatment planning with real-time optical coherence tomography (OCT) overexposure protection of the photoreceptors. This “Spectralis Centaurus” system, was built and preliminary tested on porcine ex-vivo samples, reaching an unprecedented accuracy with unique planning and follow-up capabilities for upcoming clinical cellular level micro-surgery. The combination of OCT with SRT selectively limits cell death to the RPE by precisely controlling energy deposition while optically monitoring tissue response.

Item Type:

Journal Article (Original Article)

Division/Institute:

Engineering and Information Technology > Institute for Human Centered Engineering (HUCE)
Engineering and Information Technology

Name:

Burri, Christian;
Hutfilz, Alessa;
Grimm, Lorenz Sebastian;
Arnold, Patrik;
Ebneter, Andreas;
Brinkmann, Ralf;
Theisen-Kunde, Dirk;
Povazay, Boris;
Meier, Christoph;
Lilge, Lothar D. and
Philipp, Carsten M.

Subjects:

R Medicine > RD Surgery

ISBN:

9781510628526

Publisher:

SPIE

Language:

English

Submitter:

Christoph Meier

Date Deposited:

15 Oct 2019 09:30

Last Modified:

26 Nov 2019 15:14

Publisher DOI:

10.1117/12.2526720

Additional Information:

Copyright (2019) Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited

ARBOR DOI:

10.24451/arbor.8662

URI:

https://arbor.bfh.ch/id/eprint/8662

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