Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders

Aubry, Evelyne M.; Oelhafen, Stephan; Fankhauser, Niklaus; Raio, Luigi; Cignacco Müller, Eva (2019). Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders Scientific Reports, 9(1), pp. 1-8. 10.1038/s41598-019-46179-8

Aubry et al_2019_Scientific Reports_s41598-019-46179-8.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (968kB) | Preview

Maternal obesity often occurs together with comorbid diabetes and hypertensive disorders. All three conditions are independently associated with negative perinatal outcomes. Our objective was to determine the risk and burden of adverse perinatal outcome that could be attributed to maternal obesity in combination with a comorbid status. We analyzed data from 324'664 singleton deliveries in Switzerland between 2005 and 2016. For the association of maternal obesity in the presence or absence of comorbidities with various perinatal outcomes, we estimated adjusted relative risk (RR) using multivariable regression modeling and determined the multivariable-adjusted attributable fraction of the population (AFp). Obesity was a main predictor for macrosomia, fracture of the clavicle, failure to progress in labor and prolonged labor. By stratifying women based on comorbidities, we identified significantly increased risk for preterm birth and early neonatal death only for women diagnosed with a comorbidity. However, various other outcomes were independently associated with either obesity or comorbidities. The AFp showed greatest reduction in comorbidities (15.4/15.0/13.2%), in macrosomia (6.3%) and in shoulder dystocia (4.8%) if all women were to become non-obese. We suggest that comorbidities such as diabetes and hypertensive disorders should be considered when relating maternal obesity to adverse perinatal outcomes.

Item Type:

Journal Article (Original Article)


School of Health Professions


Aubry, Evelyne M.;
Oelhafen, Stephan0000-0002-4238-6728;
Fankhauser, Niklaus;
Raio, Luigi and
Cignacco Müller, Eva0000-0001-6773-4015


R Medicine > RA Public aspects of medicine
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RG Gynecology and obstetrics




[UNSPECIFIED] Maternal Obesity




Jean Anthony Grand-Guillaume-Perrenoud

Date Deposited:

04 Nov 2019 09:13

Last Modified:

18 Dec 2020 13:28

Publisher DOI:





Actions (login required)

View Item View Item
Provide Feedback