a systematic review incorporating an indirect-comparisons meta-analysis

Hilfiker, Roger; Meichtry, Andre; Eicher, Manuela; Nilsson Balfe, Lina; Knols, Ruud H; Verra, Martin L; Taeymans, Jan (2018). a systematic review incorporating an indirect-comparisons meta-analysis British Journal of Sports Medicine, 52(10), pp. 651-658. 10.1136/bjsports-2016-096422

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Aim To assess the relative effects of different types of exercise and other non-pharmaceutical interventions on cancer-related fatigue (CRF) in patients during and after cancer treatment. Design Systematic review and indirect-comparisons meta-analysis. Data sources Articles were searched in PubMed, Cochrane CENTRAL and published meta-analyses. Eligibility criteria for selecting studies Randomised studies published up to January 2017 evaluating different types of exercise or other non-pharmaceutical interventions to reduce CRF in any cancer type during or after treatment. Study appraisal and synthesis Risk of bias assessment with PEDro criteria and random effects Bayesian network meta-analysis. Results We included 245 studies. Comparing the treatments with usual care during cancer treatment, relaxation exercise was the highest ranked intervention with a standardisedmean difference (SMD) of −0.77 (95% Credible Interval (CrI) −1.22 to −0.31), while massage (−0.78; −1.55 to −0.01), cognitive–behavioural therapy combined with physical activity (combined CBT, −0.72; −1.34 to −0.09), combined aerobic and resistance training (−0.67; −1.01 to −0.34), resistance training (−0.53; −1.02 to −0.03), aerobic (−0.53; −0.80 to −0.26) and yoga (−0.51; −1.01 to 0.00) all had moderate-to-large SMDs. After cancer treatment, yoga showed the highest effect (−0.68; −0.93 to −0.43). Combined aerobic and resistance training (−0.50; −0.66 to −0.34), combined CBT (−0.45; −0.70 to −0.21), Tai-Chi (−0.45; −0.84 to −0.06), CBT (−0.42; −0.58 to −0.25), resistance training (−0.35; −0.62 to −0.08) and aerobic (−0.33; −0.51 to −0.16) showed all small-to-moderate SMDs. Conclusions Patients can choose among different effective types of exercise and non-pharmaceutical interventions to reduce CRF.

Item Type:

Journal Article (Original Article)

Division/Institute:

School of Health Professions

Name:

Hilfiker, Roger;
Meichtry, Andre;
Eicher, Manuela;
Nilsson Balfe, Lina;
Knols, Ruud H;
Verra, Martin L and
Taeymans, Jan

Language:

English

Submitter:

Admin import user

Date Deposited:

12 Nov 2019 14:08

Last Modified:

12 Nov 2019 14:08

Publisher DOI:

10.1136/bjsports-2016-096422

ARBOR DOI:

10.24451/arbor.6698

URI:

https://arbor.bfh.ch/id/eprint/6698

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