Effect of Different Breathing Aids on Ventilation Distribution in Adults with Cystic Fibrosis.

Wettstein, Markus; Radlinger, Lorenz; Riedel, Thomas (2014). Effect of Different Breathing Aids on Ventilation Distribution in Adults with Cystic Fibrosis. PLoS One, 9(9), pp. 1-5. Public Library of Science (PLoS) 10.1371/journal.pone.0106591

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Background and objectives We investigated the effect of different breathing aids on ventilation distribution in healthy adults and subjects with cystic fibrosis (CF). Methods In 11 healthy adults and 9 adults with CF electrical impedance tomography measurements were performed during spontaneous breathing, continuous positive airway pressure (CPAP) and positive expiratory pressure (PEP) therapy randomly applied in upright and lateral position. Spatial and temporal ventilation distribution was assessed. Results The proportion of ventilation directed to the dependent lung significantly increased in lateral position compared to upright in healthy and CF. This effect was enhanced with CPAP but neutralised with PEP, whereas the effect of PEP was larger in the healthy group. Temporal ventilation distribution showed exactly the opposite with homogenisation during CPAP and increased inhomogeneity with PEP. Conclusions PEP shows distinct differences to CPAP with respect to its impact on ventilation distribution in healthy adults and CF subjects EIT might be used to individualise respiratory physiotherapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

School of Health Professions

Name:

Wettstein, Markus;
Radlinger, Lorenz0000-0002-0326-6264 and
Riedel, Thomas

ISSN:

1932-6203

Publisher:

Public Library of Science (PLoS)

Language:

English

Submitter:

Admin import user

Date Deposited:

07 Oct 2019 08:31

Last Modified:

18 Dec 2020 13:28

Publisher DOI:

10.1371/journal.pone.0106591

ARBOR DOI:

10.24451/arbor.6183

URI:

https://arbor.bfh.ch/id/eprint/6183

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