Multichannel esophageal signals to monitor respiratory rate in preterm infants

Bürgin, Corine; Simmen, Patrizia; Gupta, Nishant; Suter, Lilian; Kreuzer, Samuel; Haeberlin, Andreas; Schulzke, Sven M.; Trachsel, Daniel; Niederhauser, Thomas; Jost, Kerstin (2021). Multichannel esophageal signals to monitor respiratory rate in preterm infants Pediatric Research, 91(3), pp. 572-580. Springer 10.1038/s41390-021-01748-4

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Background Apnea of prematurity cannot be reliably measured with current monitoring techniques. Instead, indirect parameters such as oxygen desaturation or bradycardia are captured. We propose a Kalman filter-based detection of respiration activity and hence apnea using multichannel esophageal signals in neonatal intensive care unit patients. Methods We performed a single-center observational study with moderately preterm infants. Commercially available nasogastric feeding tubes containing multiple electrodes were used to capture signals with customized software. Multichannel esophageal raw signals were manually annotated, processed using extended Kalman filter, and compared with standard monitoring data including chest impedance to measure respiration activity. Results Out of a total of 405.4 h captured signals in 13 infants, 100 episodes of drop in oxygen saturation or heart rate were examined. Median (interquartile range) difference in respiratory rate was 0.04 (−2.45 to 1.48)/min between esophageal measurements annotated manually and with Kalman filter and −3.51 (−7.05 to −1.33)/min when compared to standard monitoring, suggesting an underestimation of respiratory rate when using the latter. Conclusions Kalman filter-based estimation of respiratory activity using multichannel esophageal signals is safe and feasible and results in respiratory rate closer to visual annotation than that derived from chest impedance of standard monitoring.

Item Type:	Journal Article (Original Article)
Division/Institute:	School of Engineering and Computer Science > Institute for Human Centered Engineering (HUCE) School of Engineering and Computer Science > Institute for Human Centered Engineering (HUCE) > HUCE / Laboratory for Microelectronics and Medical Devices BFH Centres and strategic thematic fields > BFH centre for Health technologies
Name:	Bürgin, Corine; Simmen, Patrizia; Gupta, Nishant; Suter, Lilian; Kreuzer, Samuel; Haeberlin, Andreas; Schulzke, Sven M.; Trachsel, Daniel; Niederhauser, Thomas0000-0003-2633-0844 and Jost, Kerstin
Subjects:	R Medicine > RJ Pediatrics T Technology > TK Electrical engineering. Electronics Nuclear engineering
ISSN:	1530-0447
Publisher:	Springer
Language:	English
Submitter:	Thomas Niederhauser
Date Deposited:	01 Dec 2021 14:09
Last Modified:	13 Mar 2022 01:35
Publisher DOI:	10.1038/s41390-021-01748-4
PubMed ID:	34601494
ARBOR DOI:	10.24451/arbor.15597
URI:	https://arbor.bfh.ch/id/eprint/15597