Serum Metabolites Responding in a Dose-Dependent Manner to the Intake of a High-Fat Meal in Normal Weight Healthy Men Are Associated with Obesity

Bütikofer, Ueli; Burnand, David; Portmann, Reto; Blaser, Carola; Schwander, Flurina; Kopf, Katrin Annika; Laederach, Kurt; Badertscher, René; Walther, Barbara; Vergères, Guy (2021). Serum Metabolites Responding in a Dose-Dependent Manner to the Intake of a High-Fat Meal in Normal Weight Healthy Men Are Associated with Obesity Metabolites, 11(6), p. 392. MDPI 10.3390/metabo11060392

Preview

Text metabolites-11-00392-v2.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (6MB) | Preview

Although the composition of the human blood metabolome is influenced both by the health status of the organism and its dietary behavior, the interaction between these two factors has been poorly characterized. This study makes use of a previously published randomized controlled crossover acute intervention to investigate whether the blood metabolome of 15 healthy normal weight (NW) and 17 obese (OB) men having ingested three doses (500, 1000, 1500 kcal) of a high-fat (HF) meal can be used to identify metabolites differentiating these two groups. Among the 1024 features showing a postprandial response, measured between 0 h and 6 h, in the NW group, 135 were dose-dependent. Among these 135 features, 52 had fasting values that were significantly different between NW and OB men, and, strikingly, they were all significantly higher in OB men. A subset of the 52 features was identified as amino acids (e.g., branched-chain amino acids) and amino acid derivatives. As the fasting concentration of most of these metabolites has already been associated with metabolic dysfunction, we propose that challenging normal weight healthy subjects with increasing caloric doses of test meals might allow for the identification of new fasting markers associated with obesity.

Item Type:	Journal Article (Original Article)
Division/Institute:	School of Agricultural, Forest and Food Sciences HAFL School of Agricultural, Forest and Food Sciences HAFL > Consumer-focused Food Production School of Agricultural, Forest and Food Sciences HAFL > Consumer-focused Food Production > Food Process Technology and Sustainable Innovation
Name:	Bütikofer, Ueli; Burnand, David; Portmann, Reto; Blaser, Carola; Schwander, Flurina; Kopf, Katrin Annika0000-0002-7443-7489; Laederach, Kurt; Badertscher, René; Walther, Barbara and Vergères, Guy
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
ISSN:	2218-1989
Publisher:	MDPI
Language:	English
Submitter:	Simon Lutz
Date Deposited:	19 Jul 2021 15:45
Last Modified:	26 Sep 2021 02:18
Publisher DOI:	10.3390/metabo11060392
Uncontrolled Keywords:	obesity; postprandial challenge; caloric-dose response; serum metabolome
ARBOR DOI:	10.24451/arbor.15182
URI:	https://arbor.bfh.ch/id/eprint/15182