Introgression of ASIP and TYRP1 Alleles Explains Coat Color Variation in Valais Goats

Henkel, Jan; Dubacher, Alexandra; Bangerter, Erika; Herren, Ursula; Ammann, Philippe; Drögemüller, Cord; Flury, Christine; Leeb, Tosso (2021). Introgression of ASIP and TYRP1 Alleles Explains Coat Color Variation in Valais Goats Journal of Heredity, 112(5), pp. 452-457. Oxford University Press 10.1093/jhered/esab024

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The Valais Blackneck goat is a Swiss goat breed with a characteristic coat color phenotype. Before the revision of the breed standard in 1938, 4 different color varieties of Valais goats were known. Besides Blackneck animals resembling the modern breed standard, the brown and white Copperneck goat, the white Capra Sempione, and the greyish Grüenochte comprised the historic Valais goats. The brown pigmentation of Copperneck goats had previously been traced back to an introgression of a mutant TYRP1 allele from Toggenburg goats. In the present study, we identified additional introgression events of distinct ASIP alleles causing the remaining 2 rare coat color patterns within the Valais Blackneck goat breed. We identified the introgression of the AWt allele from Appenzell or Saanen goats in white Capra Sempione goats. Similarly, introgression of the Apc allele from Peacock goats resulted in the greyish Grüenochte phenotype. These results demonstrate past hybridization events between breeds that are separated today. A perfect genotype-phenotype association in 393 Valais goats supported the causality of the genotyped variants for the different coat color phenotypes. Our study gives insights into the introgression of functionally relevant copy number variant (CNV) alleles controlling pigmentation between goat breeds with strikingly different coat color patterns.

Item Type:	Journal Article (Original Article)
Division/Institute:	School of Agricultural, Forest and Food Sciences HAFL School of Agricultural, Forest and Food Sciences HAFL > Agriculture School of Agricultural, Forest and Food Sciences HAFL > Agriculture > Livestock and Horses
Name:	Henkel, Jan; Dubacher, Alexandra; Bangerter, Erika; Herren, Ursula; Ammann, Philippe; Drögemüller, Cord; Flury, Christine and Leeb, Tosso
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QL Zoology S Agriculture > SF Animal culture
ISSN:	0022-1503
Publisher:	Oxford University Press
Language:	English
Submitter:	Heidi Signer-Hasler
Date Deposited:	21 Jun 2021 11:54
Last Modified:	21 Sep 2021 02:18
Publisher DOI:	10.1093/jhered/esab024
Uncontrolled Keywords:	Capra hircus, gene flow, pattern, copy number variant, agouti
URI:	https://arbor.bfh.ch/id/eprint/14958