Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality

Merker, Meret; Amsler, Aline; Pereira, Renata; Bolliger, Rebekka; Tribolet, Pascal; Braun, Nina; Hoess, Claus; Pavlicek, Vojtech; Bilz, Stefan; Sigrist, Sarah; Brändle, Michael; Henzen, Christoph; Thomann, Robert; Rutishauser, Jonas; Aujesky, Drahomir; Rodondi, Nicolas; Donzé, Jaques; Stanga, Zeno; Mueller, Beat and Schuetz, Philipp (2019). Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality Medicine, 98(48), pp. 1-9. Lippincott Williams & Wilkins 10.1097/MD.0000000000018113

[img]
Preview
Text
Vitamin_D_deficiency_is_highly_prevalent_in.44.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC).

Download (551kB) | Preview

The impact of vitamin D deficiency on the recovery of patients with malnutrition remains undefined. Our aim was to study the prevalence of vitamin D deficiency in a well-characterized cohort of patients with malnutrition and its association with outcomes.Within this secondary analysis of a randomized controlled trial, we examined the association of vitamin D deficiency and adverse clinical outcomes over a follow-up of 180 days in hospitalized patients at risk for malnutrition. We measured 25-hydroxyvitamin D levels upon admission and defined Vitamin D deficiency when levels were <50nmol/l. The primary endpoint was 180-day mortality.The prevalence of vitamin D deficiency in our cohort of 828 patients was 58.2% (n = 482). Patients with vitamin D deficiency had increased 180-day mortality rates from 23.1% to 29.9% (odds ratio 1.42, 95% confidence interval [CI] 1.03-1.94, P = .03). When adjusting the analysis for demographics, comorbidities, and randomization, this association remained significant for the subgroup of patients not receiving vitamin D treatment (adjusted odds ratio 1.63, 95% CI 1.01-2.62, P = .04). There was no significantly lower risk for mortality in the subgroup of vitamin D deficient patients receiving vitamin D treatment compared to not receiving treatment (adjusted odds ratio 0.74, 95% CI 0.48-1.13, P = .15).Vitamin D deficiency is highly prevalent in the population of malnourished inpatients and is negatively associated with long-term mortality particularly when patients are not receiving vitamin D treatment. Our findings suggest that malnourished patients might benefit from vitamin D screening and treatment in case of deficiency.

Item Type:

Journal Article (Original Article)

Division/Institute:

Health Professions

Name:

Merker, Meret;
Amsler, Aline;
Pereira, Renata;
Bolliger, Rebekka;
Tribolet, Pascal;
Braun, Nina;
Hoess, Claus;
Pavlicek, Vojtech;
Bilz, Stefan;
Sigrist, Sarah;
Brändle, Michael;
Henzen, Christoph;
Thomann, Robert;
Rutishauser, Jonas;
Aujesky, Drahomir;
Rodondi, Nicolas;
Donzé, Jaques;
Stanga, Zeno;
Mueller, Beat and
Schuetz, Philipp

ISSN:

0025-7974

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Pascal Tribolet

Date Deposited:

01 Jul 2020 15:38

Last Modified:

01 Jul 2020 15:38

Publisher DOI:

10.1097/MD.0000000000018113

ARBOR DOI:

10.24451/arbor.11784

URI:

https://arbor.bfh.ch/id/eprint/11784

Actions (login required)

View Item View Item
Provide Feedback