The LCORL Locus is under Selection in Large-Sized Pakistani Goat Breeds

Saif, Rashid; Henkel, Jan; Jagannathan, Vidhya; Drögemüller, Cord; Flury, Christine; Leeb, Tosso (2020). The LCORL Locus is under Selection in Large-Sized Pakistani Goat Breeds Genes, 11(2), p. 168. MDPI 10.3390/genes11020168

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Goat domestication and human selection for valued traits have formed diverse breeds with characteristic phenotypes. This process led to the fixation of causative genetic variants controlling breed-specific traits within regions of reduced genetic diversity—so-called “selection signatures”. We previously reported an analysis of selection signatures based on pooled whole-genome sequencing data of 20 goat breeds and bezoar goats. In the present study, we reanalyzed the data and focused on a subset of eight Pakistani goat breeds (Angora, Barbari, Beetal, Dera Din Panah, Kamori, Nachi, Pahari, Teddy). We identified 749 selection signatures based on reduced heterozygosity in these breeds. A search for signatures that are shared across large-sized goat breeds revealed that five medium-to-large-sized Pakistani goat breeds had a common selection signature on chromosome 6 in a region harboring the LCORL gene, which has been shown to modulate height or body size in several mammalian species. Fine-mapping of the region confirmed that all five goat breeds with the selection signature were nearly fixed for the same haplotype in a ~191 kb region spanning positions 37,747,447–37,938,449. From the pool sequencing data, we identified a frame-shifting single base insertion into an isoform-specific exon of LCORL as a potential candidate causal variant mediating the size-increasing effect. If this preliminary result can be confirmed in independent replication studies, genotyping of this variant might be used to improve breeding programs and the selection for stature in goats.

Item Type:	Journal Article (Original Article)
Division/Institute:	School of Agricultural, Forest and Food Sciences HAFL > Resource-efficient agricultural production systems School of Agricultural, Forest and Food Sciences HAFL > Agriculture
Name:	Saif, Rashid; Henkel, Jan; Jagannathan, Vidhya; Drögemüller, Cord; Flury, Christine and Leeb, Tosso
Subjects:	Q Science > QL Zoology S Agriculture > SF Animal culture
ISSN:	2073-4425
Publisher:	MDPI
Language:	English
Submitter:	Simon Lutz
Date Deposited:	18 Feb 2020 09:09
Last Modified:	01 Jul 2020 10:57
Publisher DOI:	10.3390/genes11020168
Uncontrolled Keywords:	Capra hircus; whole-genome sequence; body size; height; stature; QTL; selection signature; animal breeding; meat production
ARBOR DOI:	10.24451/arbor.11244
URI:	https://arbor.bfh.ch/id/eprint/11244