Individual hemoglobin mass response to normobaric and hypobaric "live high-train low": a one-year crossover study

Hauser, Anna; Trösch, Severin; Saugy, Jonas J.; Schmitt, Laurent; Cejuela-Anta, Roberto; Faiss, Raphael; Steiner, Thomas; Robinson, Neil; Millet, Grégoire P.; Wehrlin, Jon Peter (2017). Individual hemoglobin mass response to normobaric and hypobaric "live high-train low": a one-year crossover study Journal of Applied Physiology, 123(2), pp. 387-393. American Physiological Society 10.1152/japplphysiol.00932.2016

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The purpose of this research was to compare individual hemoglobin mass (Hbmass) changes following a live high-train low (LHTL) altitude training camp under either normobaric hypoxia (NH) or hypobaric hypoxia (HH) conditions in endurance athletes. In a crossover design with a one-year washout, 15 male triathletes randomly performed two 18-day LHTL training camps in either HH or NH. All athletes slept at 2,250 meters and trained at altitudes <1,200 meters. Hbmass was measured in duplicate with the optimized carbon monoxide rebreathing method before (pre) and immediately after (post) each 18-day training camp. Hbmass increased similarly in HH (916-957 g, 4.5 ± 2.2%, P < 0.001) and in NH (918-953 g, 3.8 ± 2.6%, P < 0.001). Hbmass changes did not differ between HH and NH (P = 0.42). There was substantial interindividual variability among subjects to both interventions (i.e., individual responsiveness or the individual variation in the response to an intervention free of technical noise): 0.9% in HH and 1.7% in NH. However, a correlation between intraindividual ΔHbmass changes (%) in HH and in NH (r = 0.52, P = 0.048) was observed. HH and NH evoked similar mean Hbmass increases following LHTL. Among the mean Hbmass changes, there was a notable variation in individual Hbmass response that tended to be reproducible.NEW & NOTEWORTHY This is the first study to compare individual hemoglobin mass (Hbmass) response to normobaric and hypobaric live high-train low using a same-subject crossover design. The main findings indicate that hypobaric and normobaric hypoxia evoked a similar mean increase in Hbmass following 18 days of live high-train low. Notable variability and reproducibility in individual Hbmass responses between athletes was observed, indicating the importance of evaluating individual Hbmass response to altitude training.

Item Type:	Journal Article (Original Article)
Division/Institute:	Swiss Federal Institute of Sports Magglingen SFISM > EHSM - Leistungssport > Sportphysiologie Ausdauer
Name:	Hauser, Anna; Trösch, Severin; Saugy, Jonas J.; Schmitt, Laurent; Cejuela-Anta, Roberto; Faiss, Raphael; Steiner, Thomas; Robinson, Neil; Millet, Grégoire P. and Wehrlin, Jon Peter
ISSN:	8750-7587 (Print) 1522-1601 (Online)
Publisher:	American Physiological Society
Language:	English
Submitter:	Service Account
Date Deposited:	15 Feb 2021 12:57
Last Modified:	07 Oct 2021 02:18
Publisher DOI:	10.1152/japplphysiol.00932.2016
Related URLs:	Publication
PubMed ID:	28522767
Uncontrolled Keywords:	Altitude Athletes Hemoglobin mass Hypoxia Live high-train low Training
ARBOR DOI:	10.24451/arbor.10962
URI:	https://arbor.bfh.ch/id/eprint/10962